Ordinarily each month a single article will be presented in the Article of the Month section. In the initial months several articles will be presented because these articles are the basis of the principles of my book Healthy Joints for Life. These five introductory articles will provide the scientific basis for the concept, "you are what you eat."

Studies by Neelands (1983), Vidgren (1997), Arterburn (2006), Cao (2006) and Ottestad (2012) have firmly established that the fats that form the membranes of our cells and circulate in our plasma can be specifically strongly influenced by the fats that we eat. I would encourage everyone to look at these studies so that you never have any doubt about that concept.

The fats we eat become the molecular messengers that determine whether the body is in an inflammatory or anti-inflammatory state. Start with a house builder and give him wood shingles and you end up with a wood-shingled house. Give the same builder bricks and you end up with a brick house. It's the same thing with the body. Give the body omega-3 fats and you will build anti-inflammatory molecular messengers. Alternatively, give the body omega-6 fats and you will build inflammatory messengers.

Medical science has gradually become more aware of the predominant role that inflammation plays in the development of diseases, including osteoarthritis, sometimes referred to as "wear and tear arthritis." My book Healthy Joints for Life explains how diet, exercise, and supplements can influence joint pain by counteracting inflammation. The articles below provide valuable information establishing that, through diet, we can shift the balance of inflammation vs. anti-inflammation toward anti-inflammation.

In March we will look into other scientific articles defining the molecular basis of inflammation.


  1. Neelands PJ, Clandinin MT.
    Diet fat influences liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. Biochem J. 1983: (212): 573-583.

  2. Vidgren HM, Agren JJ, Schwab U, Rissanen T, Hänninen O, Uusitupa MI.
    Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. Lipids. 1997 Jul;32(7):697-705.

    Source: Department of Clinical Nutrition, University of Kuopio, Finland. Helvi.Vidgren@uku.fi

  3. Arterburn LM, Hall EB, Oken H.
    Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S.

    Source: Martek Biosciences Corporation, Columbia, MD, USA. larterburn@martekbio.com

  4. Cao J, Schwichtenberg KA, Hanson NQ, Tsai MY.
    Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem. 2006 Dec;52(12):2265-72. Epub 2006 Oct 19.

    Source: University of Minnesota, Minneapolis, MN 55455, USA.

  5. Ottestad I, Hassani S, Borge GI, Kohler A, Vogt G, Hyötyläinen T, Orešic M, Brønner KW, Holven KB, Ulven SM, Myhrstad MC.
    Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS One. 2012;7(8):e42550. doi: 10.1371/journal.pone.0042550. Epub 2012 Aug 28.

    Source: Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.